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A 2008 study of 3,000,000 people divided the participants into groups that had taken no antibiotics for the past two years, those that had taken 2-5 prescriptions and those that had taken six or more prescriptions in the same time period.. It’s effective against HSV-1, HSV-2 and shingles Acyclovir was discovered in the 1970s and was widely used as a treatment for herpes for decades Acyclovir can be taken orally as a capsule, oral suspension, or tablet, applied as a cream, or can be injected. Acyclovir slows the growth and spread of the herpes virus in the body. Aciclovir (Zovirax) Other brand names: Cymex Ultra, Virasorb Find out how aciclovir treats cold sores, chickenpox, shingles and other herpes virus infections, and how to take it. If you have questions about side effects, call your doctor. 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